First Fix Stress Response Serum

de Mamiel

A complete first-stage solution that targets skin compromised by stress.

First Fix contains a comprehensive roster of powerhouse ingredients that work synergistically with the skin’s innate intelligence to repair and protect its functional health

The result of 13 years’ dedicated research and development, this ground-breaking response serum treats both the causes and the symptoms of stress to leave skin feeling energised, healthy and radiant. Containing a host of effective and reparative plant actives and extracts, this powerful serum will soothe, protect and repair skin back to health.

How to use

Use every evening after cleansing and toning your skin. Place 2 - 4 pumps in your palm and rub your hands together to warm and activate the serum. Breathe in the aroma deeply, then massage over your face, working outward and upward until everything is absorbed. Follow with your moisturiser and/or oil. If your skin is in intensive need of repair, use both morning and evening.

Is First Fix suitable for my skin?

If you’re feeling stressed and your skin is showing signs of confusion, then First Fix is for you. Unlike other products you may have in your skincare routine, First Fix is less about skin types and more about how your skin is feeling and behaving. Given that stress is a such a pervasive issue that affects us all, First Fix is perfectly placed to deal with any stress-related skin conditions such as lack of radiance, dryness, irritation and increased sensitivity, and help restore it back to optimal health and balance.

Is First Fix suitable for use on acne-prone skin?

First Fix is suitable for all skin types but works well on blemish-prone skin thanks to the inclusion of Distinctive Blueberry, a flavonoid which has potent anti-inflammatory and antioxidant benefits to soothe and repair inflamed and irritated skin.

Can I use First Fix if I’m pregnant?

First Fix is an excellent addition to your pregnancy skincare routine, although we advise against using it in the first trimester.

How much should I use?

Around 2-4 pumps each time you use it is plenty.

How should I apply it?
As with every de Mamiel product, the ritual of application is as important as the product; in independent psychometric testing and electroencephalography testing (EEG), First Fix was found to significantly impact the positive emotions of testers, who reported a 93% increase in feelings of pleasure after using it. To use, take a moment’s pause, apply a few pumps to fingertips and gently rub together to warm the product. Inhale deeply for a count of 3, pause, then exhale for a count of 5. Apply to skin working up and outwards from the jaw line. 

When should I use it?
As with every skincare product, it’s important to take time to listen to your skin. Although First Fix is primarily designed to be used in your evening routine, if your skin is in need of intensive repair or some extra TLC, then add it in as an extra step in your morning routine.

Where in my routine should I use it?

Use First Fix wherever you would use a serum. For use in the morning, apply after using Restorative Cleansing Balm or Pure Calm Cleansing Dew and Dewy Facial Mist, and follow with Exhale Daily Hydrating Nectar SPF30. For use in the evening, use after Restorative Cleansing Balm or Pure Calm Cleansing Dew, then follow with your Seasonal Facial Oil of choice and Skin Recovery Blend.

How long will the bottle last for?

Dependent on the usage, on average one bottle should last for approximately 70 days.

How long should I use it for?

First Fix can be used long-term as a preventative and reparative treatment.

How long will it take to see results?

This is dependent on the individual but based on our independent clinical trials, you should see results or changes in two weeks.

What does the number 21 on the bottle mean?

Number 21 represents our coming of age as a brand! First Fix is a new proposition for de Mamiel and a new commitment to future-proofing your skin. First Fix is also the 21st product in our collection.



Dermatologically tested / Dermatologically approved / Clinically tested / Suitable for all skin types including sensitive skin

Sodium Hyaluronate, Squalane and quenching oils including Prickly Pear, Kahai and Pomegranate help reduce dryness, while Neurophroline™ helps to counteract the negative effects of cortisol to visibly improve skin tone.

Ection supports a vulnerable barrier function and increase much-needed hydration, as Round-Headed Bush Clover injects skin with vitality and helps decrease the tell-tale signs of fatigue.

To address a deteriorating skin structure, there is Passioline™, an active clinically proven to support elastin and collagen synthesis for a firmer texture, while Telosense™ is included to protect and enhance skin DNA health.

Seabuckthorn Adaptogen boosts density and restores definition to skin that feels weakened, Rhodiola Rosea promotes skin energy and Blueberry Polyphenol soothes and brightens tone to reinstate skin’s innate glow.

To address the emotional impact of stress, there’s the de Mamiel Cortisol Resilience Complex™, an aromatherapeutic blend which includes Rose, Cape Chamomile, Vetiver and Sandalwood oils, and which triggers a change in the way we respond to stress.

Aqua/Water/Eau, Glycerin, Propanediol, Camellia Japonica (tsubaki) seed oil, Kappaphycus alvarezii (red algae) extract, Caryodendron orinocense (kahai) nut oil, Ectoin, Opuntia ficus indica (prickly pear) seed oil, Squalane, Helianthus annuus (sunflower) seed oil, Diheptyl succinate, Capryloyl Glycerin/Sebacic Acid Copolymer, Passiflora edulis (maracuja) seed oil, Punica granatum (pomegranate) seed oil, Cetearyl alcohol, Cetyl phosphate, L-Arginine, Benzyl alcohol, Curcuma longa (turmeric) Callus Lysate, Lespedeza capitata (roundhead bush clover) leaf/stem extract, Sodium hyaluronate, Maltodextrin, Salicylic acid, Lysolecithin, Sclerotium Gum, Tocopherol (Vitamin e), Vaccinium angustifolium (blueberry) Fruit Extract, Xanthan Gum, Parfum (Fragrance)**, Tephrosia purpurea (wild indigo) seed extract, Rhodiola Rosea (rhodiola) root extract, Vetiveria zizanoides (vetiver) root oil*, Hippophae rhamnoides (seabuckthorn) kernel extract, Pelargonium graveolens (rose geranium) leaf oil*, Santalum album (sandalwood) wood oil, Pullulan, Simmondsia chinensis (jojoba) seed oil*, Sorbic acid, Eriocephalus punctulatus (cape chamomile) flower oil*, Citric acid, Rosmarinus Officinalis (Rosemary) Leaf Extract, Sodium Benzoate, Hydrolyzed Soy Protein, Hydrolyzed Yeast Protein, Linalool˚, Citronellol˚, Geraniol˚, Citral˚ 

˚Natural essential oil constituents   


Flower and gem essences of Black-eyed Susan, Bush Fuchsia, Crowea, Jacaranda, Little Flannel Flower, Grey Spider Flower, Obsidian.