Fatigue Fix

A rejuvenating bio-active serum to revitalise tired, dry skin and restore radiance.

Fatigue Fix targets stress-induced dullness and dehydration which occurs when long-term elevated cortisol slows down cellular turnover and disrupts the protective skin barrier which in turn reduces the skin’s ability to retain moisture.

A clinically proven combination of green biotech plant actives and extracts, Fatigue Fix includes five bio-fermented minerals to oxygenate and energise the skin tissues. Polygluconic and multi-molecular Hyaluronic acids offer next generation deep hydration.

Vitamin A and peptide-rich Rock Samphire helps strengthen the skin barrier and together with Ferulic Acid keeps skin smooth. Prebiotic Glycoin and antioxidant Superoxide Dismutase help protect and repair while optical pigments provide an instant boost adding a new-found glow and radiance to the skin.

How to use

Apply morning and evening after cleansing and toning. Place 2 - 4 pumps in your palm and press hands together to warm and activate the serum. Deeply breathe in the aroma and massage into the skin, working outward and upward until completely absorbed. Follow with your moisturiser of choice.


Meticulously sourced to ensure we only use proven, pure nutrients that your body can actually use. All our ingredients are natural and formulated in the lab of de Mamiel here in the UK. Everything we do is functional, including the jars we store our product in which is violet glass to preserve the vitality of our intelligent ingredients.

Aqua/water/eau, Diheptyl succinate, Glycerin, Caprylic/Capric Triglyceride, Capryloyl Glycerin/Sebacic Acid Copolymer, Opuntia ficus-indica seed oil*, Xylitylglucoside, Olive glycerides, Anhydroxylitol, Sodium hyaluronate, Oryzanol, , Glyceryl glucoside, Propanediol, Xylitol, Saccharomyces, Zinc ferment, Copper ferment Magnesium ferment, Iron ferment Silicon ferment, Titanium dioxide, Dipalmitoyl hydroxyproline, Lysolecithin, Sclerotium gum, Ceramide NP, Citrus sinensis peel oil*, Benzyl alcohol, Xanthan gum, Pullulan, Alumina, Tocopherol, Titanium dioxide (CI 77891), Salicylic acid, Crithmum maritimum extract, Superoxide dismutase, Cananga odorata flower oil*, Glucose, Boswellia carterii resin oil, Pelargonium roseum leaf oil*, Cetyl hydroxyethylcellulose, Hydrolyzed yeast extract, Sorbic acid, Citrus bergamia peel oil*, Commiphora myrrha resin oil**, Vetiveria zizanoides root oil*, Pogostemon cablin leaf oil*, Polyglucuronic acid, Sophora japonica flower extract, Rosa centifolia flower oil, Mica, Tin oxide, CI 77491 (Iron oxides), Lavandula angustifolia flower/leaf oil, Jasminum officinale flower oil*, Lecithin, Silicate mineral, Potassium sorbate, Sodium benzoate  Citronellol ̊, Geraniol ̊, Isoeugenol ̊, Limonene ̊, Linalool ̊  Flower and gem essences of Black-eyed Susan, Bush Fuchsia, Crowea, Jacaranda, Little Flannel Flower, Grey Spider Flower, Obsidian.Natural essential oil constituents*Organic**Wild Harvested


Sustainability has always been at the heart of the de Mamiel brand. Now very topical, it’s an integral part of our DNA. Packaging is essential to the Beauty Industry, and we are continually looking for ways to reduce our impact on the planet whilst protecting the precious ingredients we use and providing you with the best experience we can offer.

Our products come to you in either Miron violet glass or airless pumps which preserve the ingredients from UV light, ensuring that they arrive in the most vital and efficacious form. In 2019 we introduced our Conscious Packaging allowing you to choose to receive your products without individual boxes and in 100% recyclable packaging.

If you would prefer to receive your products in their original boxes, then, of course, that option is still there. Simply tick the Signature Wrapping box at the checkout and we will box and wrap your products in our giftable packaging.

For those choosing Conscious Packaging, as a little thank you on behalf of the planet, we will plant a tree for every order at One Tree Planted in Australia, assisting Annee’s homeland in their recovery from the devasting bushfires.

We put Fatigue Fix to the test

We sent Fatigue Fix to 102 testers on an independent blind trial, here’s what they said

85% of testers said their skin appears REVITALISED

84% of testers said their skin appears REJUVENATED

86% of testers said their skin appears BRIGHTER

"I wish I had known the name of this serum as I would gladly buy it over and over again. It's a wonderful product that leaves my complexion looking good and refreshed. My skin loves it. Absolutely amazing serum!" - Tester 11

"My skin has definitely improved using this serum within a short amount of time I can see a noticeable difference with the texture of my skin. It's way more soft, energised and brighter, the smell is beautiful I would highly recommend." - Tester 75